Royal Air Force Typhoon jets have joined forces with France's air force in a coordinated attack against an subterranean weapons facility in Syrian territory used by the IS group, according to the UK's MoD.
The site, located using intelligence, was thought to be storing arms and explosives, the release indicated, and was located in hills just north of Palmyra in Syria's central region.
"Our aircraft used precision-guided Paveway IV munitions to hit a series of access tunnels down to the site... early reports indicate the target was engaged successfully," the MoD said.
There was no indication of any harm to civilians in the operation on Saturday evening and all the aircraft returned safely, the defence officials confirmed.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
IS - referred to as ISIS - established extremist governance over parts of Syria and Iraq prior to its 2019 collapse.
"This operation shows our UK leadership, and determination to operate in unison with our allies, to eradicate any re-emergence of the terrorist group and their harmful and extremist ideologies in the Middle East," UK Defence Secretary the minister said.
British military aircraft have carried out surveillance missions over Syrian airspace to "deter any attempted comeback" of Islamic State after its defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I must thank all the members of our armed forces participating in this mission for their expertise and their valour," Healey added. "They were among thousands of British personnel stationed over Christmas and New Year. This operation, to take out terrorist threats who pose a risk to our way of life, highlights how British military are ready to step up, all year round, ensuring Britain's security within its borders and influential overseas."
During December, the United States armed forces carried out what it called a "massive strike" against IS targets in Syria, following an assault resulted in the deaths of two American soldiers and a local interpreter in Palmyra.
The United Nations reports Islamic State still has roughly 5-7 thousand fighters in Iraq and Syria.
